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1

High-Level Expression of Human Liver Monoamine Oxidase B in Pichia pastoris

Paige Newton-Vinson, Frantisek Hubalek, Dale E. Edmondson

Journal:

Protein Expression and Purification

Year:

2000

Language:

english

File:

PDF, 125 KB

english, 2000

2

Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover

Manka, Jason T., Vinson, Paige N., Gregory, Karen J., Zhou, Ya, Williams, Richard, Gogi, Kiran, Days, Emily, Jadhav, Satya, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.57 MB

english, 2012

3

Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold

Rodriguez, Alice L., Zhou, Ya, Williams, Richard, David Weaver, C., Vinson, Paige N., Dawson, Eric S., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M., Macdonald, Gregor J., Sco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

4

Quantitative microdialysis of serotonin and norepinephrine: Pharmacological influences on in vivo extraction fraction

Rebecca J.Olson Cosford, A.Paige Vinson, Shola Kukoyi, Joseph B. Justice Jr

Journal:

Journal of Neuroscience Methods

Year:

1996

Language:

english

File:

PDF, 1.02 MB

english, 1996

5

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold

Richard Williams, Jason T. Manka, Alice L. Rodriguez, Paige N. Vinson, Colleen M. Niswender, C. David Weaver, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

6

Microdialysis of dopamine interpreted with quantitative model incorporating probe implantation trauma

Peter M. Bungay, Paige Newton-Vinson, Wanda Isele, Paul A. Garris, Joseph B. Justice Jr

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 502 KB

english, 2003

7

Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders

Binda, Claudia, Newton-Vinson, Paige, Hubálek, Frantisek, Edmondson, Dale E., Mattevi, Andrea

Journal:

Natural Structural Biology

Year:

2001

Language:

english

File:

PDF, 1.64 MB

english, 2001

8

Discovery of N-Aryl Piperazines as Selective mGluR5 Potentiators with Improved In Vivo Utility

Manka, Jason T., Rodriguez, Alice L., Zhou, Ya, Weaver, C. David, Days, Emily L., Vinson, Paige N., Jadhav, Satyawan, Hermann, Elizabeth J., Jones, Carrie K., Conn, P. Jeffrey

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

9

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: Unexpected ‘molecular switch’ from a closely related mGlu4 positive allosteric modulator

Thomas Utley, Dustin Haddenham, James M. Salovich, Rocio Zamorano, Paige N. Vinson, Craig W. Lindsley, Corey R. Hopkins, Colleen M. Niswender

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.52 MB

english, 2011

10

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM

Douglas J. Sheffler, Cody J. Wenthur, Joshua A. Bruner, Sheridan J.S. Carrington, Paige N. Vinson, Kiran K. Gogi, Anna L. Blobaum, Ryan D. Morrison, Mitchell Vamos, Nicholas D.P. Cosford, Shaun R. Sta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.58 MB

english, 2012

11

Phentermine inhibition of recombinant human liver monoamine oxidases A and B

Ravi K. Nandigama, Paige Newton-Vinson, Dale E. Edmondson

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 107 KB

english, 2002

12

High-Level Expression of Human Liver Monoamine Oxidase A in Pichia pastoris: Comparison with the Enzyme Expressed in Saccharomyces cerevisiae

Min Li, Frantis̆ek Hubálek, Paige Newton-Vinson, Dale E. Edmondson

Journal:

Protein Expression and Purification

Year:

2002

Language:

english

File:

PDF, 445 KB

english, 2002

13

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

James M. Salovich, Paige N. Vinson, Douglas J. Sheffler, Atin Lamsal, Thomas J. Utley, Anna L. Blobaum, Thomas M. Bridges, Uyen Le, Carrie K. Jones, Michael R. Wood, J. Scott Daniels, P. Jeffrey Conn,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 4.28 MB

english, 2012

14

Metabotropic glutamate receptors as therapeutic targets for schizophrenia

Paige N. Vinson, P. Jeffrey Conn

Journal:

Neuropharmacology

Year:

2012

Language:

english

File:

PDF, 346 KB

english, 2012

15

The Covalent FAD of Monoamine Oxidase: Structural and Functional Role and Mechanism of the Flavinylation Reaction

Edmondson, Dale E., Newton-Vinson, Paige

Journal:

Antioxidants & Redox Signaling

Year:

2001

Language:

english

File:

PDF, 338 KB

english, 2001

16

Erratum

Manka, Jason T., Vinson, Paige N., Gregory, Karen J., Zhou, Ya, Williams, Richard, Gogi, Kiran, Days, Emily, Jadhav, Satya, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M.,

Journal:

Nutrition Research

Year:

1993

File:

PDF, 18 KB

1993

17

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

Turlington, Mark, Noetzel, Meredith J., Bridges, Thomas M., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Tong, Han Min, Macdon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 995 KB

english, 2014

18

Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

Le, Uyen, Melancon, Bruce J., Bridges, Thomas M., Vinson, Paige N., Utley, Thomas J., Lamsal, Atin, Rodriguez, Alice L., Venable, Daryl, Sheffler, Douglas J., Jones, Carrie K., Blobaum, Anna L., Wood,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.00 MB

english, 2013

19

Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

Rook, Jerri M., Noetzel, Meredith J., Pouliot, Wendy A., Bridges, Thomas M., Vinson, Paige N., Cho, Hyekyung P., Zhou, Ya, Gogliotti, Rocco D., Manka, Jason T., Gregory, Karen J., Stauffer, Shaun R.,

Journal:

Biological Psychiatry

Year:

2013

Language:

english

File:

PDF, 1.22 MB

english, 2013

20

Discovery of ML326: The first sub-micromolar, selective M5 PAM

Gentry, Patrick R., Bridges, Thomas M., Lamsal, Atin, Vinson, Paige N., Smith, Emery, Chase, Peter, Hodder, Peter S., Engers, Julie L., Niswender, Colleen M., Scott Daniels, J., Jeffrey Conn, P., Wood

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.09 MB

english, 2013

21

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu 5 )

Turlington, Mark, Malosh, Chrysa, Jacobs, Jon, Manka, Jason T., Noetzel, Meredith J., Vinson, Paige N., Jadhav, Satyawan, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, Jos

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.86 MB

english, 2014

22

Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu 5 ) Positive Allosteric Modulators (PAMs): Discovery of 5-((3-Fluorophenyl)ethynyl)- N -(3-methyloxetan-3-yl)picolinamide (ML254)

Turlington, Mark, Noetzel, Meredith J., Chun, Aspen, Zhou, Ya, Gogliotti, Rocco D., Nguyen, Elizabeth D., Gregory, Karen J., Vinson, Paige N., Rook, Jerri M., Gogi, Kiran K., Xiang, Zixiu, Bridges, Th

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.74 MB

english, 2013

23

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

Rook, Jerri M., Xiang, Zixiu, Lv, Xiaohui, Ghoshal, Ayan, Dickerson, Jonathan W., Bridges, Thomas M., Johnson, Kari A., Foster, Daniel J., Gregory, Karen J., Vinson, Paige N., Thompson, Analisa D., By

Journal:

Year:

2015

Language:

english

File:

PDF, 2.69 MB

english, 2015

24

Discovery of VU0409551/JNJ-46778212: An mGlu 5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 973 KB

english, 2015

25

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators

Malosh, Chrysa, Turlington, Mark, Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceid

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 978 KB

english, 2015

26

Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury

Skrypnyk, Nataliya I, Sanker, Subramaniam, Brilli-Skvarca, Lauren, Novitskaya, Tatiana, Woods, Clara, Chiba, Takuto, Patel, Kevin, Goldberg, Natasha D, McDermott, Lee, Vinson, Paige N, Calcutt, Marion

Journal:

AJP: Renal Physiology

Year:

2015

Language:

english

File:

PDF, 2.42 MB

english, 2015

27

Selective small molecule activators of TREK-2 channels stimulate DRG c-fiber nociceptor K2P currents and limit calcium influx

Dadi, Prassana K., Vierra, Nicholas Catin, Days, Emily L., Dickerson, Matthew, Vinson, Paige N, Weaver, C. David, Jacobson, David A.

Journal:

ACS Chemical Neuroscience

Year:

2016

Language:

english

File:

PDF, 4.98 MB

english, 2016

28

Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992

Kharade, Sujay V., Kurata, Haruto, Bender, Aaron, Blobaum, Anna L., Figueroa, Eric, Duran, Amanda M., Kramer, Meghan, Days, Emily, Vinson, Paige, Flores, Daniel, Satlin, Lisa M., Meiler, Jens, Weaver,

Journal:

Molecular Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.10 MB

english, 2018

29

Resurrecting an antibody against an alternative conformation of cytochrome c: the recombinant mAb 1D3

Radi, Rafael, Tomasina, Florencia, Piacenza, Lucía, Castellana, Natalie, Goff, Matt, Cooper, Tracy, McDonald, Hayes, Seaback, Stacey, Vinson, Paige, Carnahan, Robert, Jemmerson, Ronald

Journal:

Free Radical Biology and Medicine

Year:

2018

Language:

english

File:

PDF, 54 KB

english, 2018

30

Comparative analysis of myometrial and vascular smooth muscle cells to determine optimal cells for use in drug discovery

Siricilla, Shajila, Knapp, Kelsi M., Rogers, Jackson H., Berger, Courtney, Shelton, Elaine L., Mi, Dehui, Vinson, Paige, Condon, Jennifer, Paria, Bibhash C., Reese, Jeff, Sheng, Quanhu, Herington, Jen

Journal:

Pharmacological Research

Year:

2019

Language:

english

File:

PDF, 962 KB

english, 2019

31

Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

Fulton, Mark Gallant, Loch, Matthew Thomas, Cuoco, Caroline Anne, Rodriguez, Alice Lambert, Days, Emily, Vinson, Paige Newton, Kozek, Krystian Andrezej, Weaver, Charles David, Blobaum, Anna Louise, Co

Journal:

Letters in Drug Design & Discovery

Year:

2019

Language:

english

File:

PDF, 3.01 MB

english, 2019

32

Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

Fulton, Mark Gallant, Loch, Matthew Thomas, Cuoco, Caroline Anne, Rodriguez, Alice Lambert, Days, Emily, Vinson, Paige Newton, Kozek, Krystian Andrezej, Weaver, Charles David, Blobaum, Anna Louise, Co

Journal:

Letters in Drug Design & Discovery

Year:

2019

File:

PDF, 3.01 MB

2019

33

Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D

Aggarwal, Geetika, Zarrow, Jonah E., Mashhadi, Zahra, Flynn, C. Robb, Vinson, Paige, Weaver, C. David, Davies, Sean S.

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 515 KB

2020